It plays an important role in the process of maturity and differentiation of B cells. There are not available that BAFF expression and the predictive value on treatment outcome in patients with CHIR-99021 in vitro chronic hepatitis C (CHC). Methods: 175 CHC patients were enrolled with PEG-IFNα-2a (180 μg, qw) / RBV (800-1200mg/d) treatment for at least 12w. IL28B SNP rs12979860 and rs8099917 and HCV genotype were detected

at baseline, while serum ALT, AST, TBIL, HCV RNA loads and BAFF levels were detected before and 4w, 12w after treatment. BAFF levels were assessed on 58 health blood donors (HBD). To compare BAFF levels among these three groups, and analyze predictors to RVR in patients after antivirus treatments. Results: 1.BAFF levels in patients with RVR (median 2400.0pg/ml) were higher than that in patients without (median 1731.6pg/ml) and than that in HBD (median 1095.9pg/ml), successively, P<0.05. The lowest BAFF level was 724pg/ml in this study. 2. HCV genotype, IL28BSNP rs12979860 and rs8099917 genotype, HCV RNA and BAFF baseline were included in the logistic regression analysis

and ROC was drawn to evaluate predict value of BAFF to RVR. After calculation IL28B SNP rs12979860 genotype and BAFF become influence factors to RVR. This was a logistic regression equation: Y=2.427-0.001 xBAFF-2.013×lL28BSNP rs12979860 (coded CC Genotype as 1 and non-CC as 0, Y=0.3614 according to the ROC cut-off point) . If a patient with CC genotype or non-CC genotype whose BAFF baseline were above ADP ribosylation factor 52.5pg/ml or 2065.5pg/ml, the AUROC achieved 79.6% (Figure 1). Conclusions: 1. BAFF expression INCB018424 datasheet in patients with hepatitis C-infected is higher than HBD.

2. BAFF is a predictor to RVR in patients with IL28BSNP rs12979860 non-CC genotype after antivirus therapy. There is higher RVR rate in patients with CC genotype regardless of others indexes. Figure l: ROC curve in prediction on BAFF to 1^ R after logistic regression analysis-Note: AUROC curve values (95% CI) were 0.796(0.684-0.908), cut-off point is 0.361, sensitivity is 0.904, specificity is 0-696, negative predictive value is 0.762,.P=0.000 Disclosures: The following people have nothing to disclose: Jing Liu, Zhen Xu, Wen-Xiong Xu, Zhi-Shuo Mo, Xiang Zhu, Zhi-liang Gao Although recent studies indicate that supplementation of vitamin D significantly improves a sustained viral response by IFN-based therapy to chronic hepatitis C, detailed mechanisms for the role of vitamin D are not fully elucidated. Previously, we demonstrated that the metabolite of vitamin D, 25-hydroxyvita-min D, has the direct anti-viral effect against hepatitis C virus (HCV) targeting infectious virus production. Since vitamin D is known to be multi-functional, we reasoned that other anti-viral functions of vitamin D, especially through immunomodulatory activity, should be considered.