A nurse is allocated to and makes contact with the carer to welcome them into the programme and to determine the agreed level of support to be offered throughout the 12-week programme. The support service at the time of the collection of the data described here was restricted to phone

calls but has since been expanded to include newsletters and motivational and reminder text messages which can be opted out of at any time. Capmatinib clinical trial During the current 12-week programme the carer will on average receive six calls of approximately 15 min duration, six newsletters, two motivational Inhibitors,research,lifescience,medical texts per week and two reminder texts per appointment. The calls, newsletters and texts mirror the themes of the first 12 weeks on atomoxetine and will include topics such as side effects, efficacy and daily routine. At Inhibitors,research,lifescience,medical the end of the 12 weeks the carer completes a satisfaction survey to provide feedback on the service. Phase 5: clinician feedback. The final phase occurs when the nurse ensures that the clinician has received feedback on the

carers referred into the service. If atomoxetine has been stopped the clinician receives a discontinuation letter advising how long the carer was in the service and the reason for discontinuation. If the carer completes the 12-week service the clinician receives a discharge summary advising how the carer progressed through the 12 weeks, any issues that had been discussed and the outcomes achieved. Inhibitors,research,lifescience,medical During this final phase the clinician also feeds back on their experience of using the service. The Lilly Global Patient Safety Inhibitors,research,lifescience,medical team trains the SSS nurses annually on the capturing and reporting of all adverse events which are raised through the interactions with the carers. The following sections describe outcomes from the service offered at the time when newsletters and text messages had not been introduced. Methods Data are presented descriptively without formal statistics and represent a service evaluation and not any form of clinical research. Data from all patients who initiated atomoxetine in the service between 1 January 2009 and 31 March 2010 were available Inhibitors,research,lifescience,medical for analysis. Patients

who were enrolled in the service but did not start atomoxetine were not included in the analysis. Continuation rates were assessed at week 12 and were defined as the number of patients in the service who were taking many atomoxetine at that stage. Patients were considered adherent if they reported taking atomoxetine at week 12 regardless of whether treatment had been interrupted prior to week 12. Continuation rates from the service were then compared with historical market research data provided by the market research company Cegedim. From the 450 practices in Primary Care using InPS Vision clinical software, Cegedim selected 150 of the practices most representative of UK regional populations. Data from these practices include duration of therapy.