AREB recognized

that rabies mAbs can effect a change in the PEP for category III exposures in Asia. Since they can be produced in large quantities, they would be more widely accessible in endemic areas. Rabies mAbs could even fully replace currently available RIGs, if their safety, and efficacy are established in phase III studies and if their activity against circulating rabies virus strains is confirmed. AREB acknowledged and supported the resolution to eliminate rabies by 2016 adopted by Sri Lanka, and that of the ASEAN Plus Three Countries2 and India to eliminate rabies by 2020. Some Asian countries, however, have not yet adopted rabies control policies and sheep brain vaccine is still produced and/or used in Bangladesh, Pakistan and Myanmar. Rabies has re-emerged in some regions, e.g. in Bali, formerly a rabies-free island, where it has claimed more than 20 human lives since its re-introduction in 2008. In China, the number of Enzalutamide concentration reported human rabies cases had declined between 1990 and 1996, with the lowest number of cases reported in 1996 (n = 159). Since 1997, however, the number of human rabies cases has increased exponentially with a peak of 3300 reported rabies deaths in 2007. There is an estimated population of 80–200 million dogs in

China [17], and 85–95% of all human rabies cases were reported to result from bites from infected dogs. Thus, the domestic dog continues to play a pivotal role in rabies transmission in China. Human cases are reported in almost all provinces of China, except Qinghai and Tibet, with most cases occurring in southern China, where the human-to-dog Talazoparib chemical structure no ratio is substantially higher than in the rest of the country. An internet-based national reporting

system has been established for notifiable diseases, including rabies, and a sentinel surveillance system for rabies has been in place since 2005. An investigation conducted recently by the China Center for Disease Control and Prevention showed that only 32% of victims with a category III animal bite received adequate wound treatment and only 31% were compliant with the full course of PEP. The low number of PEPs in the study was attributed to a lack of awareness of rabies. Recently, the Ministry of Health revised the national criteria for human rabies diagnosis and the national guidelines for rabies PEP; governmental offices will be involved in implementation of the National Rabies Control Program. Reviewing studies investigating newly conducted vaccination regimens, and proposals calling for implementation of some of these new regimens, AREB members emphasized the need for clear, simplified PEP protocols—ideally no more than two IM and two ID regimens. Adding new PEP schedules would increase the complexity of patient management, although it could also be considered to improve flexibility in the adaptation of PEP to specific situations.