End points of interest were objective response rate (ORR), overall survival (OS), and event-free survival (EFS). Statistical analysis To estimated ORR, the patients were divided into responders and non-responders. The responders were defined as complete response (CR) and partial response (PR) and the non-responders including stable disease
(SD) and progressive disease (PD). The pooled odds ratio (OR) and its 95% confidence intervals (CIs) were calculated by the methods proposed by Mantel and Haenszel , or by DerSimonian R and Laird N . For time-to-event data-OS and EFS, the hazard ratios (HRs) and associated 95% confidence interval (CI) were Nocodazole mouse estimated using the methods reported by Parmar . The between study heterogeneity
was determined by Q test and I 2 metric (I 2 = 0–25%: no heterogeneity; I 2 = 25–50%: moderate heterogeneity; I 2 = 50–75%: large heterogeneity; I 2 = 75–100%: extreme heterogeneity) . The fixed-effect model was applied in the initial analysis, and if the significant selleck chemicals llc heterogeneity existed, then the confirmed random-effect model was used. Begg’s test was click here used to evaluate the publication bias. P < 0.05 indicated significant publication bias . All P value was two-tailed, and STATA version 11.1 (Stata Corporation, USA) was used to perform the most of data analysis. Results Eligible studies 188 potentially relevant studies were identified HAS1 through the search strategy. After checking the title and abstract, 134 studies excluded because it was very clear that their design didn’t meet our inclusion criteria. Then the full texts of 54 articles were carefully screened, 29 studies were excluded as data insufficiency that we could not extract the data for analysis, 2 studies were excluded for potential data overlap
as the same institute conducted the research and their patients recruitment time may exist overlap. Finally, a total of 23 studies were eligible for the final analysis. Among them, 19 studies estimated the relationship between BRCA1 and platinum-based chemotherapy outcome [10, 16–33], 3 were toxal-based [34–37]. Additional one studies evaluated the toxal-based in fist-line chemotherapy and a part of patients received platinum-based treatment . The study selection process was showed in Figure 1. Figure 1 The flow chart of study selection and exclusion. Study characteristics Our meta-analysis composed 23 studies [10, 16–37] including 2606 NSCLC patients. The sample size variant from 34 to 769, 17 studies were about East-Asian population [16–25, 27, 28, 30, 32–34, 37], 5 studies were about Caucasian [10, 26, 29, 35, 36] and 1 studies may contain different races as the samples were from the prospective randomized clinical trial International Adjuvant Lung Trial (IALT) .