Gastroenterology 2011, 141:98–105.PubMedCrossRef 13. Cole BF, Baron JA, Selleckchem Ferrostatin-1 Sandler RS, Haile RW, Ahnen DJ, Bresalier RS, McKeown-Eyssen G, Summers RW, Rothstein RI, Burke CA, Snover DC, Church TR, Allen JI, Robertson DJ, Beck GJ, Bond JH, Byers T, Mandel JS, Mott LA, Pearson LH, Barry EL, Rees JR, Marcon N, BAY 11-7082 datasheet Saibil F, Ueland PM, Greenberg ER, Polyp Prevention Study Group: Folic acid for the prevention of colorectal adenomas: a randomized clinical trial. JAMA 2007, 297:2351–9.PubMedCrossRef
14. Sie KK, Medline A, van Weel J, Sohn KJ, Choi SW, Croxford R, Kim YI: Effect of maternal and postweaning folic acid supplementation on colorectal cancer risk in the offspring. Gut 2011, 60:1687–94.PubMedCrossRef MI-503 mw 15. Lonn E, Yusuf S, Arnold MJ, Sheridan P, Pogue J, Micks M, McQueen MJ, Probstfield J, Fodor G, Held C, Genest J Jr: Heart Outcomes Prevention Evaluation (HOPE) 2 Investigators Homo-cysteine lowering with folic acid and B vitamins in vasculardisease. N Engl J Med 2006, 354:1567–1577.PubMedCrossRef 16. Fife J, Raniga S, Hider PN, Frizelle FA: Folic acid supplementation and colorectal cancer risk: a meta-analysis. Colorectal Dis 2011, 13:132–7.PubMedCrossRef 17. Carroll C, Cooper K, Papaioannou D, Hind D, Tappenden P, Pilgrim H, Booth A: Meta-analysis: folic
acid in the chemoprevention of colorectal adenomas and colorectal cancer. Aliment Pharmacol Ther 2010, 31:708.PubMedCrossRef 18. Kim YI: Folic acid supplementation and cancer risk: point. CancerEpidemiol Biomarkers Prev 2008, 17:2220–2225.CrossRef 19. Bird RP: Role of aberrant crypt foci in understanding the pathogenesis of colon cancer. Cancer Lett 1995, 93:55–71.PubMedCrossRef 20. Pretlow TP, O’Riordan MA, Pretlow TG, Stellato TA: Aberrant crypts in human colonic mucosa: putative preneoplastic lesions. RG7420 clinical trial J Cell Biochem Suppl 1992, 16G:55–62.PubMedCrossRef 21. Lindzon GM, Medline A, Sohn KJ, Depeint F, Croxford R, Kim YI: Effect of folic acid supplementation on
the progression of colorectal aberrant crypt foci. Carcinogenesis 2009, 30:1536–43.PubMedCrossRef 22. Lee JE, Willett WC, Fuchs CS, Smith-Warner SA, Wu K, Ma J, Giovannucci E: Folate intake and risk of colorectal cancer and adenoma: modification by time. Am J Clin Nutr 2011, 93:817–25.PubMedCrossRef 23. Le Leu RK, Young GP, McIntosh GH: Folate deficiency reduces the development of colorectal cancer in rats. Carcinogenesis 2002, 21:2261–5.CrossRef 24. Dempke WC, Heinemann V: Kas mutational status is a biomarker for resistance to EGFR inhibitors in colorectal carcinoma. Anticancer Res 2010, 30:4673–7.PubMed 25. Heinemann V, Stintzing S, Kirchner T, Boeck S, Jung A: Clinical relevance of EGFR- and KRAS-status in colorectal cancer patients treated with monoclonal antibodies directed against the EGFR. Cancer Treat Rev 2009, 35:262–271.PubMedCrossRef 26.