Here we provide genetic evidence that Prdm14, a PR domain-containing transcriptional regulator Y-27632 in vitro with exclusive expression in the germ cell lineage and pluripotent cell lines, is critical in two of these events, the reacquisition of potential pluripotency and successful epigenetic reprogramming. In Prdm14 mutants, the failure of these two events manifests even in the presence of Prdm1 (also known as Blimp1), a key transcriptional regulator for PGC specification(6,7). Our combined evidence demonstrates that Prdm14 defines a previously unknown genetic pathway, initiating independently from Prdm1, for ensuring the launching of the mammalian germ cell

lineage.”
“Ultracold Fermi gases with tunable interactions provide a test bed for exploring the many-body physics of strongly interacting quantum systems(1-4). Over the past decade, experiments have investigated many intriguing Transmembrane Transporters inhibitor phenomena, and precise measurements of ground-state properties have provided benchmarks for the development of theoretical descriptions. Metastable states in Fermi gases with strong repulsive interactions(5-11) represent an exciting area of development. The realization of such systems is challenging, because a strong repulsive interaction in an atomic quantum gas implies the existence of a weakly bound molecular state, which makes the system intrinsically unstable against decay. Here we use radio-frequency spectroscopy to measure

the complete excitation spectrum of fermionic K-40 impurities resonantly interacting with a Fermi sea of Li-6 atoms. In particular, we show that a well-defined quasiparticle exists for strongly repulsive interactions. We measure IWR-1-endo cost the energy and the lifetime of this ‘repulsive polaron’(9,12,13), and probe its coherence properties by measuring the quasiparticle residue. The results are well described by a theoretical approach that takes into account the finite effective range of the interaction in our system. We find that when the effective range is of the order of the interparticle spacing, there is a substantial increase in the lifetime of the quasiparticles. The existence of such a long-lived, metastable

many-body state offers intriguing prospects for the creation of exotic quantum phases in ultracold, repulsively interacting Fermi gases.”
“American water shrews (Sorex palustris) are aggressive predators that dive into streams and ponds to find prey at night. They do not use eyesight for capturing fish or for discriminating shapes. Instead they make use of vibrissae to detect and attack water movements generated by active prey and to detect the form of stationary prey. Tactile investigations are supplemented with underwater sniffing. This remarkable behavior consists of exhalation of air bubbles that spread onto objects and are then re-inhaled. Recordings for ultrasound both above and below water provide no evidence for echolocation or sonar, and presentation of electric fields and anatomical investigations provide no evidence for electroreception.