Table 2 Baseline characteristics according to the category of proteinuria at 1 year of follow-up Variables Category of UPE at 1 year of follow-up (g/day) p value Disappeared (<0.3) Mild (0.30–0.39) Moderate (0.40–0.99) Severe (≥1.00) Number of patients 80 23 22 16   Age (years) 35 (26–44) 30 (25–42) 32 (26–36) 35 (26–42) >0.2 Female 39 (48.8) 11 (47.8) 12 (54.5) 9 (56.3) >0.2 Current smokers 18 (22.5) 5 (21.7) 6 (27.3) 5 (31.3)

>0.2 BP >130/80 mmHg 25 (31.3) 9 (39.1) 5 (22.7) 4 (25.0) >0.2 UPE (g/day) 0.82 MLN2238 (0.57–1.28) 0.80 (0.64–2.17) 1.58 (0.97–2.28) 1.90 (1.25–2.80) <0.001# U-RBC >30/hpf 48 (60.0) 12 (52.2) 8 (36.4) 9 (56.3) >0.2 eGFR (ml/min/1.73 m2) 75.1 ± 27.1 73.7 ± 29.1 68.2 ± 29.5 66.3 ± 29.1 >0.2 eGFR <60 25 (31.3) 10 (43.5) 10 (45.5) 6 (37.5) >0.2 Tonsillectomy 40 (50.0) 10 (43.5) 12 (54.5) 6 (37.5) >0.2 RAAS inhibitors 35 (43.8) 9 (39.1) 11 (50.0) 7 (43.8) >0.2 Values are presented as numbers (%), medians (IQR) or mean ± SD BP blood pressure, UPE urinary protein excretion, U-RBC urinary sediments of red blood cells, eGFR estimated glomerular filtration rate. # p < 0.05 Renal GS-4997 nmr survival according to the UPE category at 1 year by Kaplan–Meier analysis and multivariate Cox model The results of the univariate time-dependent analyses by the Kaplan–Meier method are shown in Fig. 3. GSK2399872A Patients in the Disappeared and Mildcategories showed significantly better renal survival compared to the Moderate or Severe categories

(log-rank, p < 0.05 for both strata), whereas there was no such difference between the Moderate and Severe categories (log-rank, p > 0.2). Fig. 3 Renal survival determined by the Kaplan–Meier method, stratified by the category of UPE at 1 year after 6 months of steroid therapy. These unadjusted curves demonstrate that, in addition to the Disappeared category, the Mild category showed significantly better renal survival compared to that in the Moderate or Severe categories (log-rank, p < 0.05 for both strata) The clinical predictors for the endpoint in the Cox–hazard model

are presented in Table 3. Relative to the Severe category in the multivariate model, the Disappeared and Mild categories were favorable predictors, with risk reduction of approximately 90 and 70 %, respectively, whereas the Moderate category was not associated with renal survival. In contrast, eGFR <60 ml/min/1.73 m2 CHIR-99021 cost at baseline was an unfavorable predictor. Clinical remission, as well as a U-RBC <5/hpf at 1 year after steroid therapy, was not associated with renal survival in the univariate model. Table 3 Clinical predictors for a 50 % increase in serum creatinine from the baseline level in the Cox–hazard model Predictors Univariate model Multivariate modela HR (95 % CI) p value HR (95 % CI) p value At 1 year  Category of proteinuriab   Disappeared c 0.07 (0.01–0.33) 0.001# 0.06 (0.01–0.57) 0.014#   Mild c 0.10 (0.12–0.80) 0.030# 0.02 (0.00–0.29) 0.003#   Moderate c 0.55 (0.16–1.98) >0.2 0.24 (0.04–1.25) 0.