The exact mechanisms for both protective and destructive pathways are not clear and are still under investigation. Improved understanding

of morphine neuroprotection and neurotoxicity will be helpful to control morphine side effects in medical applications and to identify new targets for potential therapies and prevention strategies to opioid addiction. NEUROSCIENTIST 14(6): 561-570, 2008. DOI: 10.1177/1073858408314434″
“Voltage-gated Na(+) channels (VGSCs) exist as macromolecular complexes containing a pore-forming alpha subunit and one or more beta subunits. The VGSC alpha subunit gene family consists of 10 members, which have distinct tissue-specific and developmental expression profiles. So far, four beta subunits (beta 1-beta 4) and one splice variant of beta 1 (beta 1A, also called selleck compound beta 1B) have been identified. VGSC beta subunits are multifunctional, serving as modulators of channel activity, regulators of channel cell surface

expression, and as members of the immunoglobulin superfamily, cell adhesion molecules (CAMs) beta subunits are substrates of beta amyloid precursor protein-cleaving enzyme (BACE1) and Talazoparib cell line gamma-secretase, yielding intracellular domains (ICDs) that may further modulate cellular activity via transcription. Recent evidence shows that beta 1 regulates migration and pathfinding in the developing postnatal CNS in vivo. The alpha and beta subunits, together

with other components of the VGSC signaling complex, may have dynamic interactive roles depending on cell/tissue type, developmental stage, and pathophysiology. In addition to excitable cells like nerve and muscle, VGSC alpha and beta subunits are functionally expressed in cells that are traditionally considered nonexcitable, including glia, vascular endothelial https://www.selleck.cn/products/th-302.html cells, and cancer cells. In particular, the alpha subunits are up-regulated in line with metastatic potential and are proposed to enhance cellular migration and invasion. In contrast to the alpha subunits, beta 1 is more highly expressed in weakly metastatic cancer cells, and evidence suggests that its expression enhances cellular adhesion. Thus, novel roles are emerging for VGSC alpha and beta subunits in regulating migration during normal postnatal development of the CNS as well as during cancer metastasis. NEUROSCIENTIST 14(6):571-583, 2008. DOI: 10.1177/1073858408320293″
“The adult cerebral cortex possesses the remarkable ability to change its neuronal connectivity through experience, a phenomenon termed “”synaptic plasticity.”" Synaptic plasticity constitutes a cellular mechanism that is thought to underlie information storage and memory formation in the brain, and represents a use-dependent long-blasting increase or decrease in synaptic strength.