This review focuses on the

role of activity-dependent protein acetylation in synaptic plasticity and memory. (C) 2010 Elsevier Ltd. All rights reserved.”
“Purpose: PCA3 is a prostate specific noncoding mRNA that is significantly over expressed in prostate cancer tissue. Urinary PCA3 levels have been associated selleck screening library with prostate cancer grade and extent, suggesting a possible role in monitoring patients on active surveillance. We assessed the relationship between PCA3 and prostate biopsy results in men in a surveillance program.

Materials and Methods: Urine specimens were obtained from 294 men with prostate cancer enrolled in the Johns Hopkins surveillance program. The follow-up protocol included semiannual free and total prostate specific antigen measurements, digital rectal selleck chemical examination and annual surveillance prostate biopsy. Cox proportional hazards regression was used to evaluate the association between PCA3 results and progression on surveillance biopsy (defined as Gleason pattern 4 or 5, more than 2 positive biopsy cores or more than 50% involvement of any core with cancer).

Results: Patients with progression on biopsy (12.9%) had a mean PCA3 score similar to that of those without progression (60.0 vs 50.8, p = 0.131). ROC analysis suggested that PCA3

alone could not be used to identify men with progression on biopsy (AUC 0.589, 95% CI 0.496-0.683, p = 0.076). After adjustment for age and date of diagnosis PCA3 was not significantly associated with progression on biopsy (p = 0.15).

Conclusions: In men with low risk prostate cancer who were carefully selected for surveillance 3-Methyladenine solubility dmso the PCA3 score was not significantly associated with short-term biopsy progression. Further analysis is necessary to assess the usefulness of PCA3 in combination with other biomarkers or in selected subsets of patients undergoing surveillance.”
“The literature on the creative

personality is curiously equivocal in its characterization of the traits supposedly possessed by eminent creators. While acclaimed as revolutionary and pioneering visionaries, the same category of people can come across as unsocialized and discomfiting even to their close associates and admirers. This paper suggests that these ambiguities can be addressed by appealing to the potential psychobiological mechanisms that can give rise to the expression of both creative ability and “”antisocial”" traits. Work on latent inhibition, the somatic marker hypothesis. Eysenck’s biosocial theory of crime and the dopamine hypothesis of addiction are reviewed and integrated into a model that examines the role of dopamine as a critical agent in the creative personality system. Finally, testable hypotheses stemming from the model are proposed. (C) 2010 Elsevier Ltd. All rights reserved.