Using this approach, some patients may have been diagnosed with TB without ever receiving confirmation and/or treatment, and the actual study population with TB may be lower than estimated by this study. This research confirms that treatment with bDMARDs in patients with RA is associated with a higher risk of TB, as well as with risk for incident lymphoma, compared GSK126 supplier with tDMARDs. Additionally, risk of adverse events (in particular, SBI and TB) vary based on bDMARD type, with a higher risk associated with the monoclonal antibody therapy adalimumab, as compared to etanercept, a soluble receptor fusion protein. This study expands

the evidence base for differential risk of infection posed by specific HKI-272 mouse bDMARDs. This study was based in part on data from the Taiwan National Health Insurance Research Database provided by the Bureau of National Health Insurance,

Department of Health and managed by National Health Research Institutes. The interpretation and conclusions contained herein do not represent those of the Bureau of National Health Insurance, Department of Health or National Health Research Institutes. Ming-Ta Yang is an employee of IMS Health who was a paid consultant to Pfizer in connection with the development of this manuscript. Vernon F. Schabert was an employee of IMS Health who was a paid consultant to Pfizer during the development of the study and manuscript. This study was funded by Pfizer Inc. Ya-Wen Yang is an employee Fluorouracil of Pfizer Taiwan. Chi-Hui Fang and Boxiong Tang were employees of Pfizer during the development of the study and manuscript. “
“International Journal of Rheumatic Diseases is entering its second phase of existence. It was born into APLAR in 1997 and nurtured by Prof Ken Muirden as it marched ahead into early

childhood as APLAR Journal of Rheumatology; it then grew further under the editorship of Professor P H Feng. Prof CS Lau inherited it, renamed it as International Journal of Rheumatic Diseases in recognition of APLAR’s global goals and was instrumental in having it indexed initially in Science citation index-extended (SCI-E) and subsequently in Medline. The journal is at the threshold of entering young adulthood today with a modest, but growing impact factor of 0.807. Its publisher Wiley has provided the right grooming to achieve all its feats of success till date. The Journal is still in its formative years and needs more nutrition in terms of Science and Art of Rheumatology to become a truly international journal. While the aspirations of our APLAR region including science from disadvantaged regions will be kept in mind, uncompromising quality will be the topmost priority of the new editorial team. An overwhelming willingness to join my team by top experts and scientists from all across the globe in response to my request was reassuring.