We propose future research to assess the effects of oral ATP admi

We propose future research to assess the check details effects of oral ATP administration on blood flow in a placebo-controlled crossover or parallel design. Conclusion Oral ATP administration can increase blood flow, and this effect is particularly prominent following exercise. Increased blood flow due to ATP supplementation may be the mechanism responsible for ergogenic

effects following chronic ATP supplementation as previously reported in the scientific literature. However, the exact mechanism whereby ATP increases blood flow during post-exercise recovery periods SN-38 solubility dmso remains unknown and future investigation in this area is warranted. Acknowledgements We are grateful for the support from TSI, Sapitinib Missoula, MT, for funding this study. References 1. Agteresch HJ, Dagnelie PC, van den Berg JW, Wilson JH: Adenosine triphosphate: established and potential clinical applications. Drugs 1999,58(2):211–232.PubMedCrossRef 2. Bannwarth B, Allaert F-A, Avouac B, Rossignol M, Rozenberg S, Valat J-P: A randomized, double-blind,

placebo controlled study of oral adenosine Triphosphate in subacute low back pain. J Rheumatol 2005, 32:1114–1117.PubMed 3. Jordan AN, Jurca R, Abraham EH, Salikhova A, Mann JK, Morss GM, Church TS, Lucia A, Earnest CP: Effects of oral ATP supplementation on anaerobic power and muscular strength. Med Sci Sports Exerc 2004,36(6):983–990.PubMedCrossRef 4. Rathmacher JA, Fuller JC Jr, Baier SM, Abumrad NN, Angus HF, Sharp RL: Adenosine-5′-triphosphate (ATP) supplementation improves low peak muscle torque and torque fatigue during repeated Cepharanthine high intensity exercise sets. J Int Soc Sports Nutr 2012,9(1):48.PubMedCentralPubMedCrossRef 5. Sprague RE, Bowles EA, Achilleus D, Ellsworth ML: Erythrocyte as controllers of perfusion distribution in the microvasculature skeletal muscle.

Acta Physiol 2011, 202:285–292.CrossRef 6. Wilson JM, Joy JM, Lowery RP, Roberts MD, Lockwood CM, Manninen AH, Fuller JC Jr, De Souza EO, Baier SM, Wilson SMC, Rathmacher JA: Effects of oral adenosine-5′-triphosphate (ATP) supplementation on athletic performance, skeletal muscle hypertrophy and recovery in resistance-trained men. Nutr Metab (Lond) 2013, 10:57.CrossRef 7. May C, Weigl L, Karel A, Hohenegger M: Extracellular ATP activates ERK1/ERK2 via a metabotropic P2Y1 receptor in a Ca2+ independent manner in differentiated human skeletal muscle cells. Biochem Pharmacol 2006,71(10):1497–1509.PubMedCrossRef 8. Rosenmeier JB, Hansen J, Gonźalez-Alonso J: Circulating ATP-induced vasodilatation overrides sympathetic vasoconstrictor activity in human skeletal muscle. J Physiol 2004, 558:351–365.PubMedCentralPubMedCrossRef 9.

Comments are closed.