01) than that from the usual brand condition (5,841 �� 4,004 ml), whereas the total puff volume from the VLNC + PLA condition (5,268 �� 3,309 ml) was intermediate and did not significantly differ from either of those conditions. There was no significant effect of cigarette type on CO boost and no significant interaction between diagnosis selleckchem Volasertib and cigarette type on either measure. Subjective Effects of Sensorimotor and Nicotine Replacement Figure 1 shows the effects of sensorimotor and nicotine replacement on QSU-brief, MNWS, and Habit Withdrawal scores in SS and CS. SS reported significantly higher MNWS and Habit Withdrawal scores than CS (F(1, 50) = 22.10, p < .001; F(1, 50) = 6.84, p < .05; respectively). Averaged across nicotine and sensorimotor replacement conditions, MNWS scores were 34.

1 �� 23.1 in SS and 12.8 �� 12.7 in CS, and Habit Withdrawal scores were 3.9 �� 1.5 in SS and 2.9 �� 1.8 in CS. There was no effect of diagnosis on QSU-brief score. Figure 1. Effects of 5-hr exposure to 42 mg transdermal nicotine (NIC) or placebo patches (PLA) and very low nicotine content cigarettes (VLNC Cigs) or no cigarettes (No Cigs) on CO boost, urge to smoke, nicotine withdrawal symptoms and habit withdrawal symptoms … There were significant main effects of sensorimotor replacement on QSU-brief, MNWS, and Habit Withdrawal scores (F(1, 50) = 84.75, p < .001; F(1, 50) = 38.77, p < .001; F(1, 50) = 13.36, p < .01; respectively), with lower scores from the VLNC cigarette conditions compared with the no cigarette conditions. Averaged across diagnostic groups and nicotine replacement conditions, QSU-brief scores were 5.

0 �� 1.5 in the no cigarette and 3.2 �� 1.8 in the VLNC cigarette condition, MNWS scores were 29.5 �� 24.1 in the no cigarette and 17.3 �� 20.8 in the VLNC cigarette condition, and Habit Withdrawal scores were 3.7 �� 1.8 in the no cigarette and 3.1 �� 1.6 in the VLNC cigarette condition. There were no significant interactions between diagnosis and sensorimotor replacement on these measures. There was a significant main effect of nicotine replacement on QSU-brief score (F(1, 50) = 8.56, p < .01), and the effect of nicotine replacement on MNWS score approached significance (F(1, 50) = 3.21, p = .08; d = 0.16). Averaged across diagnostic groups and sensorimotor replacement conditions, QSU-brief scores were 3.9 �� 1.7 in the NIC condition and 4.

3 �� 1.6 in the PLA condition, and MNWS scores were 21.7 �� 22.32 in the NIC condition and 25.2 �� 22.52 in the PLA condition. There were no significant Diagnosis �� Nicotine Replacement or Sensorimotor Replacement �� Nicotine Replacement interactions on these measures. However, there was a significant Diagnosis Carfilzomib �� Sensorimotor Replacement �� Nicotine Replacement interaction effect on Habit Withdrawal score (F(1, 50) = 5.44, p < .05).