During a median follow-up of 2 7 years, 110 adults

(16 5%

During a median follow-up of 2.7 years, 110 adults

(16.5%) had cognitive decline. Among the measures of gait performance (speed, step length, and frequency), step length AZD6094 supplier was the most predictive of cognitive decline. After controlling for important confounders, older men in the lowest and middle tertiles of step length at maximum speed and older women in the lowest and middle tertiles of step length at usual speed were 4.42 (95% confidence interval: 1.65-11.8), 2.17 (0.82-5.71), 5.76 (2.15-15.4), and 2.44 (0.94-6.35) times as likely to develop cognitive decline, respectively, as those of the same sex and walking speed who were in the highest tertile.

Step length was an independent predictor of cognitive decline in a general population of older adults and may be a better predictor than overall gait speed of such decline.”
“Patients with epilepsy are at high risk for major depression relative to the general population, and both disorders are PD98059 supplier associated with changes in adult hippocampal neurogenesis, although the mechanisms underlying disease onset remain unknown. The expression of fosB, an immediate

early gene encoding FosB and Delta FosB/Delta 2 Delta FosB by alternative splicing and translation initiation, is known to be induced in neural progenitor cells within the subventricular zone of the lateral ventricles and subgranular zone of the hippocampus, following transient forebrain ischemia in the rat brain. Moreover,

adenovirus-mediated expression of fosB gene products can promote neural stem cell proliferation. We recently found that fosB-null mice show increased depressive IMP dehydrogenase behavior, suggesting impaired neurogenesis in fosB-null mice. In the current study, we analyzed neurogenesis in the hippocampal dentate gyrus of fosB-null and fosB(d/d) mice that express Delta FosB/Delta 2 Delta FosB but not FosB, in comparison with wild-type mice, alongside neuropathology, behaviors, and gene expression profiles. fosB-null but not fosB(d/d) mice displayed impaired neurogenesis in the adult hippocampus and spontaneous epilepsy. Microarray analysis revealed that genes related to neurogenesis, depression, and epilepsy were altered in the hippocampus of fosB-null mice. Thus, we conclude that the fosB-null mouse is the first animal model to provide a genetic and molecular basis for the comorbidity between depression and epilepsy with abnormal neurogenesis, all of which are caused by loss of a single gene, fosB. Neuropsychopharmacology (2013) 38, 895-906; doi: 10.1038/npp.2012.260; published online 16 January 2013″
“The aim of the present study was to investigate the prevalence of hypotension in older participants and to identify which 24-hour ambulatory blood pressure monitoring parameter better correlated with the occurrence of hypotension.

We studied 588 elderly participants (mean age 78.7 +/- 7.

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