Databases including PubMed, AlzGene, China National Knowledge Infrastructure (CNKI) and Wan Fang were searched to find relevant studies.
Odds ratios (ORs) with 95% confidence intervals (CIs) were used to assess the strength of association. All analyses were calculated using STATA Version 11.0 and RevMan (v.5.1) software. Ten total case-control studies were included. The statistical results showed that GAB2 SNP rs2373115 is significantly associated with an increased risk for SAD, and the subgroup analysis showed that SNP rs2373115 may only be associated with an increased risk for SAD risk in Caucasians but not in Asians. Furthermore, in APOE epsilon 4 carriers or noncarriers, those with rs2373115 genotype GG did not have a significantly higher Semaxanib concentration risk for SAD compared with those with genotype GT and IT (APOE epsilon 4 carriers: OR = 1.20,95% CI = 0.92-1.56, P = 0.178; APOE epsilon 4 noncarriers: OR = 1.08, 95% CI = 0.97-1.20, P = 0.157) in the present study. The current meta-analysis further supports previous findings that the GAB2 gene may be associated with SAD risk. (C) 2013 Elsevier Ireland Ltd. All rights reserved.”
“The development of an effective prophylactic vaccine is still necessary to improve the safety of the conventional
although-discontinued smallpox vaccine, and to protect from the threat of deliberate release of variola virus. This need also arises from the number of new cases of animal orthopoxvirus infections each year, and to reduce the risk to animal handlers. Fowlpox (FP) IWR-1 recombinants only replicate in avian species and have been Suplatast tosilate developed against human infectious diseases, as they can elicit an effective immune response, are not cross-reactive immunologically with vaccinia, and represent safer and more promising immunogens for immunocompromised individuals. The aim of this study was the characterisation of two new fowlpox recombinants expressing the A33R vaccinia virus gene either alone (FRA33R) or with the green fluorescent protein (FPA33R-GFP) to verify whether GFP can affect the expression
of the transgene. The results show that both FPA33R and FPA33R-GFP can express A33R correctly, but A33R mRNA and protein synthesis are higher by FPA33R than by FPA33R-GFP. Therefore, GFP co-expression does not prevent, but can reduce the level of a vaccine protein, and may affect the protective efficacy of the immune response. (C) 2012 Elsevier B.V. All rights reserved.”
“Coactivator-associated arginine methyl transferase 1 (CARM1) is a protein arginine methyltransferase (PRMT) family member that functions as a coactivator in androgen and estrogen signaling pathways and plays a role in the progression of prostate and breast cancer. CARM1 catalyzes methylation of diverse protein substrates. Prior attempts to purify the full-length mouse CARM1 protein have proven unsatisfactory. The full-length protein expressed in Escherichia coli forms insoluble inclusion bodies that are difficult to denature and refold.