pylori eradication

was analyzed using the Kaplan–Meier method, and the difference between the curves of open- and closed-type was tested by Log-rank test. A Cox’s proportional hazards regression model was used to analyze independence of the association Cilomilast order between the extent of green mucosa in AFI images and development of metachronous EGC. Age, sex, intestinal metaplasia in the lesser curvature of the corpus, serum pepsinogen status, and H. pylori status were selected as candidate covariates for multivariate analysis. P < 0.05 was considered to indicate statistical significance. Eighteen patients in whom AFI endoscopy was not available and who did not undergo AFI observation were excluded, which left a total of 82 patients who were followed up and analyzed. The patients' demographic and clinical characteristics are shown in Table 1. In the AFI images, 31 patients had open-type, chronic atrophic fundic gastritis, and 51 had closed type. Stem Cells antagonist Among 82 patients who were analyzed, 73 were H. pylori-positive and received eradication therapy, while the remaining nine patients were negative and were not prescribed anti-H. pylori treatment. In 58 of 73 H. pylori-positive patients, the first eradication therapy was successful,

and second-line therapy was successful in five patients. Thus, a total of 72 patients were followed up as an H. pylori negative group. Ten patients who failed first- and second-line eradication therapy were followed up as a persistent H. pylori infection group (Fig. 3). All participants received follow-up endoscopy (median duration of follow-up period, 55 months; range, 14–72 months). Metachronous EGC developed

in nine (12.5%) of 72 patients without H. pylori infection, and in three (30.0%) of 10 patients who had persistent H. pylori infection (Fig. 3). All metachronous EGC detected had a small size (mean tumor size, 6.0 ± 3.6 mm), was confined to the mucosa, find more and could be treated by ESD. Pathologically, all EGC was of the differentiated type. The most suitable cut-off points for pepsinogen for metachronous EGC, obtained by receiver operating characteristic curve, were pepsinogen I ≤ 22 ng/mL or pepsinogen I/II ratio ≤ 1.8. Using the most suitable cut-off point for pepsinogen I/II ratio, the sensitivity and specificity for metachronous EGC was 63.6% and 41.0%, respectively. Investigating predictive factors by univariate analysis, age (P = 0.028), intestinal metaplasia in the lesser curvature of the corpus (P = 0.012), and open-type atrophic fundic gastritis diagnosed by AFI (P < 0.001) were significantly associated with the development of metachronous EGC (Table 2). The cumulative 4-year incidence of metachronous EGC was 27.8% in patients with open-type atrophic fundic gastritis diagnosed by AFI and 4.1% in those with closed type, respectively (P < 0.001, Fig. 4).

Most importantly, previous studies have not examined the relationship between each of the three distinct patterns of hepatic iron deposition and histological severity among patients with NASH. The goal of the current study was to analyze the relationships between the pattern of hepatic iron deposition and liver histology in liver biopsy specimens from an unselected cohort of NAFLD patients prospectively enrolled in the National Institutes for Health–funded Gemcitabine Nonalcoholic Steatohepatitis Clinical Research Network (NASH CRN) from eight participating centers in the United States. ALT, alanine aminotransferase; AST, aspartate aminotransferase; BMI, body mass index;

CI, confidence interval; HC, hepatocellular; HCC, hepatocellular carcinoma; HDL, high-density lipoprotein; HFE, hemochromatosis gene; HJV, hemojuvelin; HOMA-IR, homeostasis model assessment of insulin resistance; IL, interleukin; LDL, low-density lipoprotein; NAFLD, nonalcoholic fatty liver disease; NAS, nonalcoholic fatty liver disease activity score; NASH, nonalcoholic steatohepatitis; NASH CRN, Nonalcoholic Steatohepatitis Clinical Research Network; OR, odds ratio; RES, reticuloendothelial system; ROS, reactive oxygen species;

TFR, transferrin receptor; TIBC, total iron-binding capacity; TS, transferrin saturation. Participants were see more enrolled in the NASH CRN studies from October 2005 to February 2008 according to inclusion criteria described elsewhere.18, 19 Briefly, NASH CRN study participants at least 18 years of age constituted the selleck chemicals llc patient population for this study. Patients with known hemochromatosis (defined as a hepatic iron index ≥ 1.9 or the removal of >4 g of iron by phlebotomy), C282Y homozygosity for the HFE gene, or unexplained hepatic iron overload (≥3+ stainable iron on liver biopsy) were excluded from all NASH CRN studies. Demographic information such as age, gender, ethnicity, and race was obtained. A medical history was obtained for all subjects; it included a menstrual history for

women, the presence of comorbid conditions, and medication usage. The total dietary consumption of iron, vitamin C, tea, and coffee was determined with the Block 98 food frequency questionnaire; alcohol consumption was determined with the Alcohol Use Disorders Identification Test–Consumption questionnaire during the NASH CRN studies closest to the time of biopsy. A physical examination, which included body weight and height measures, was performed for all subjects. The histological evaluation was based on 849 liver biopsy samples with hepatic iron staining results, which were read centrally by the pathology committee of NASH CRN. In addition, clinical and laboratory data obtained within 6 months of liver biopsy were compared between iron stain–positive subjects and iron stain–negative subjects if they were available (n = 573).

Key Word(s): 1. endoscopic treatment; 2. biliary pancreatitis; 3. elder; Presenting Author: WENJING SUN Additional Authors: XIAOCHUN SHENG, YAN CAO, HAIYAN LIU, CHUNHUI LAN, DONGFENG CHEN Corresponding Author: WENJING SUN Affiliations: Hospital Objective: To evaluate the guidance value of EUS and CT scan in preoperative clinical staging for diagnosis and treatment of esophageal cancer. Methods: 68 patients with esophageal cancer were randomized in a 1 : 1 ratio using a random numbers table. Patients in EUS group were examined by EUS and staged according

to the TNM staging system (2003). Patients in the other group were examined by CT scan. The EUS findings were compared with surgical pathologic findings. Results: The accuracy rates of T staging by EUS were0.0% (0/2) for Tis, 75.0% (3/4) for Tl, 75.0% (6/8) for T2, 86.7% (13/15) for T3, 80.0% (4/5) for T4, and 76.5% (26/34) for T; PLX3397 in vivo those of N staging were 71.4% (5/7)

for N0, 75% (9/12) for N1, 0.0% (0/11) for N2, 0.0% (0/4) for N3, and 41.2% (14/34) for N. The accuracy rates of T staging by CT scan were 0% (0/1) for Tis, 33.3% (2/6) for T1, 28.6% (2/7) for T2, 78.6% (11/14) for T3, 83.3% (5/6) for T4 and 58.8% (20/34) for T (p = 0.005); those of N staging were77.8% (7/9) for N0, 76.9% (10/13) for N1, 66.7% (4/6) for N2, 50% (3/6) for N3 and 70.6% (24/34) for N (p = 0.005). Conclusion: The accuracy rates of EUS are higher for diagnosis Lenvatinib chemical structure in esophageal cancer and preoperative T staging. The accuracy rates of CT scan are higher for the preoperative N staging. EUS combined with CT scan has great significance selleck chemical for choosing ideal therapy plan for esophageal cancer, and for estimating prognosis of esophageal cancer. Key Word(s): 1. EUS; 2. CT scan; 3. esophageal cancer; 4. clinical staging; Presenting Author: PING HE Additional Authors: ZHUO ZHAO, YUJIA LIU,

HONG XU Corresponding Author: PING HE Affiliations: The First Hospital of Jilin University.; the First Hospital of Jilin University Objective: To evaluate the method of abdominal ultrasound-guided percutaneous endoscopic gastrostomy (PEG) safety and feasibility in clinical work, to give patients the best, safest treatment. Methods: 21 in patients of the First Bethune Hospital of Jilin University carried the percutaneous endoscopic gastrostomy (PEG) through intraoperative abdomen ultrasound of the anterior abdominal wall scan of the position of the abdominal wall and stomach wall closest, looking for the best abdominal wall puncture point, to avoid injure the vessels and vital organs in the abdomen. Results: Abdominal ultrasound-guided percutaneous endoscopic gastrostomy (PEG) was performed in 21 cases, the success rate was 100%; average operation time was 21.5 minutes, the process had no bleeding, vice injury in complications; with the surveillance of 3 months to 4 years, the PEG tube patency and normal use, and no PEG late complications occurred.