In addition, this study will attempt to determine cutoff point for WBCs and neutrophils counts with best sensitivity
and specificity for determination of acute appendicitis. Material Osimertinib and methods Four hundred and fifty six patients (273 male and 183 female) who underwent appendectomy with a clinical diagnosis of AA in Surgery Department at King Abdulaziz Medical Center, Jeddah, Saudi Arabia were recruited in this retrospective study between January 2003 and January 2007. The diagnosis of AA was established by history, clinical examination, and laboratory tests including WBCs and neutrophil counts. Demographic, symptoms, signs, surgical procedures, and histopathological results of appendix examination
were recorded. Patients who underwent incidental appendectomy as part of another procedure, and patients on steroids or immunosuppressive Mdivi1 purchase medications excluded from the study. According to the results of histopathological examination of the removed appendix, patients were divided into 3 groups, group (1) normal appendix (no pathological diagnosis) (n = 29); group (2) with unS63845 price complicated inflamed appendicitis (n = 350) and group (3) with complicated appendicitis (n = 77) (perforated and gangrenous). The ethical committee of King Abdelaziz University approved the study. Laboratory tests were carried on admission to hospital before antibiotics administered. WBCs count and differential were measured by an automated hematology analyzer counter (SE-9000; Sysmex, Kobe, Japan). All the excised appendices were underwent histopathological examination. Data analysis The statistical analysis was performed using MedCalc for Windows, version 5.0 (MedCalc Software, Mariakerke, Belgium) and Statistical Package for the Social Sciences for Windows, version
12.0 (SPSS Inc., Chicago, IL, USA). The data were expressed as mean +/− stander deviation [SD] (range) or number (%) as appropriate. Statistical analysis was done with one-way analysis of variance to compare data between groups. For comparison of 2 groups unpaired Student ”t test” and Chi square test were used for parametric and non-parametric parameters, respectively. For describing Meloxicam the diagnostic properties of WBCs and neutrophils counts, we used the area under ROC curve (AUC) and likelihood ratio (LR) . AUC of 1.00 indicates perfect discriminating power while area of 0.50 indicates absence of discriminating power. LR (+) is the ratio of the frequency of a finding among the diseased patients (true-positive rate) and among the non-diseased patients (false-positive rate). A true diagnostic test usually has an LR >10, and an exclusion test has a LR < 0.1. All results were reported with 95% confidence intervals (95% CIs). A P value of < 0.05 was considered statistically significant. Results Table 1 showed patients’ demographic characteristics.